Regensburg 2002 – wissenschaftliches Programm
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SYBM: Physik biologischer Materie
SYBM 401: Physics of biological matter: Poster
SYBM 401.40: Poster
Dienstag, 12. März 2002, 18:00–19:30, H37
Rheology of Glycocalix Model at Interface — •Motomu Tanaka1, Matthias Schneider1, Kwangmo Lim2, and Gerald Fuller2 — 1Lehrstuhl für Biophysik E22, Technische Universität München, D-85748 Garching — 2Chemical Engineering Department, Stanford University, Stanford, CA 94305-5025
The rheology of glycocalix model compounds was studied using an interfacial stress rheometer (ISR) to understand the complex interplay of various forces (e.g. electrostatic interaction, van der Waals force, and hydrogen bonding) operating on cellular surfaces. The viscous and elastic surface moduli of the monolayer of synthetic glycolipids with oligolactose head groups (named as Lac 1, 2, and 3) were measured as a function of the length of the linear oligosaccharide head groups quantitatively. The ISR device allows for highly sensitive and real-time measurements of viscoelastic parameters at different frequencies under controlled thermodynamic conditions (surface pressure, temperature). The observed rheological transition, where the hydrating water is excluded and hydrogen bonding No-dqbridgesNo-dq the oligosaccharide head groups, can model a generic function of glycocalix to stabilize the plasma membrane structure.