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DY: Dynamik und Statistische Physik

DY 46: Poster

DY 46.48: Poster

Donnerstag, 27. März 2003, 15:30–18:00, P1

Emergent Network Structure, Dynamics and Evolution of an Artificial Genome — •Thimo Rohlf¹, Chris Winkler², and Stefan Bornholdt¹ — ¹Interdiziplinäres Zentrum für Bioinformatik (IZBI), University of Leipzig, Kreuzstraße 7b, D-04102 Leipzig, Germany — ²Pioneer Hi-Bred International, 7250 NW 62nd Ave, Johnston IA 50131 USA

Regulatory interactions between genes in biological organims, mediated by transcription factors binding to specific regions of the genome, form complex dynamical networks. A clear understanding of the structure and dynamics of these networks is not yet at hand. Here, we investigate these properties within an artificial genome model [1]. We show that this model accurately predicts the frequency of genes in real genomes, and gives a statistical distribution of regulatory inputs consistent with experimental data. Evolution of genome structure by random sequence mutations and selection for dynamical characteristics is studied. The statistical properties of the evolved systems are compared to randomly constructed genomes.

[1] Reil, T. in Fifth European Conference on Artificial Life, Eds. D. Floreano et al., Springer Verlag, Berlin 1999