Regensburg 2004 – wissenschaftliches Programm

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AKB: Biologische Physik

AKB 41: Cell Signaling

AKB 41.1: Hauptvortrag

Donnerstag, 11. März 2004, 17:00–17:30, H40

Identification of Sensory Transduction Chains in vivo — •Andreas Herz and Tim Gollisch — Institute for Theoretical Biology, Humboldt University Berlin, Invalidenstrasse 43, 10115 Berlin

Every sensation begins with the conversion of a sensory stimulus into the response of a receptor neuron. Typically, this involves a multi-step sequence of multiple biophysical processes that cannot all be monitored directly. Here we present a method that makes it possible to extract their dynamical features by comparing different stimuli that cause the same output, the only signal to be measured. Applied to auditory receptor cells, this novel technique reveals sub-millisecond details of mechanosensory signal processing and yields a quantitative four-step signal transduction model. Owing to its simplicity and generality, the method is readily applicable to a large variety of signal-processing systems.