Regensburg 2004 – wissenschaftliches Programm

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SYNP: Functional Nanoparticles

SYNP 1: Functional Nanoparticles - I

SYNP 1.3: Hauptvortrag

Dienstag, 9. März 2004, 10:45–11:15, H1

Biomedical Applications of Magnetic Nanoparticles — •Lutz Trahms — Laboratory for Bioelectricity and Biomagnetism, Physikalisch-Technische Bundesanstalt Berlin, D-10587 Berlin, Germany

Magnetic nanoparticles (MNP) having dimensions ranging from a few nanometers up to a few hundred nanometers may be employed as smart in-vivo probes, which develop their activity only after external stimulation. Taking advantage of their particular interaction with externally applied homogeneous or inhomogeneous constant or time dependent magnetic fields, MNP can be utilised for a variety of biomedical applications. Magnetic drug targeting and MNP-coupled hyperthermia are promising new therapies, which may improve the prognosis for cancer patients. A couple of years ago MNP were introduced into radiological diagnostics as a new contrast agent for magnetic resonance imaging. Yet little attention has been given to the applicability of SQUIDs for localising and quantifying the amount of MNP accumulated in human tissue. With their high sensitivity to the magnetic relaxation of MNP, SQUID relaxometry of MNP could become another useful diagnostic method, in particular for monitoring MNP-based therapies.