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AKB: Biologische Physik

AKB 200: Poster Session II

AKB 200.24: Poster

Dienstag, 8. März 2005, 17:00–19:00, Poster TU C

Molecular recognition of chemically structured substrates in a lattice model — •Thorsten Bogner, Andreas Degenhard, and Friederike Schmid — Condensed Matter Theory, Fakultät für Physik, University of Bielefeld, Universitätsstraße 25, E5 [5th floor]

We investigate the adsorption of polypeptides on a planar substrate by means of a coarse grained model on a lattice. The chemical composition of both, the peptide and the substrate, is modeled explicitly.

In particular we are interested in the emergence of specificity within the adsorption process. Despite its simplicity, we expect our model to exhibit the basic properties that lead to molecular recognition in ’real world’ experiments. By analyzing the results of the simulations using methods from statistical data analysis, we find the small-scale structures of the peptide sequence to be a particular important factor regarding specificity. This is in qualitative agreement with existing binding experiments.