Berlin 2005 – wissenschaftliches Programm

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AKB: Biologische Physik

AKB 200: Poster Session II

AKB 200.7: Poster

Dienstag, 8. März 2005, 17:00–19:00, Poster TU C

Supramolecular Interaction at the Single Molecule Level — •Rainer Eckel¹, Robert Ros¹, Björn Decker², Jochen Mattay², and Dario Anselmetti¹ — ¹Experimentelle Biophysik und Angewandte Nanowissenschaften, Universität Bielefeld, Universitätsstrasse 25, 33615 Bielefeld — ²Organische Chemie, Universität Bielefeld, Universitätsstrasse 25, 33615 Bielefeld

In supramolecular systems, the tailored non-covalent interaction between designed organic host and guest molecules opens fascinating concepts for the development of new materials for artificial molecular recognition, self-assembly and biosensor applications. We applied mechanical single molecule force spectroscopy to investigate the specific binding of individual resorc[4]arene-ligand host-guest complexes. The molecular binding forces, their dependence to external loading rates, the rate of dissociation, and its corresponding cavity length directly relate to the molecular properties of the supramolecular species and are consistent with an activated decay of a metastable bound state(1). This allows new insights into the mechanisms, kinetics and thermodynamics of intermolecular association in chemical and biological receptor systems.

(1) R. Eckel, R. Ros, B. Decker, J. Mattay, and D. Anselmetti, Angew. Chem. (in press).