Berlin 2005 – wissenschaftliches Programm
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CPP: Chemische Physik und Polymerphysik
CPP 29: POSTER: Polymer physics
CPP 29.1: Poster
Dienstag, 8. März 2005, 16:30–18:30, Poster TU D
PEGylated Membranes - A SANS study on brushes and mushrooms — •Beate Klösgen1, Kell Mortensen2, and Lise Arleth3 — 1University of Southern Denmark, Phys. Dept. and MEMPHYS, Odense, Denmark — 2The Danish Polymer Center, Risø, Denmark — 3Royal Veterinary and Agricultural University, Frederiksberg, Denmark
Polyethylene glycol (PEG) polymers tethered to lipids were proposed as shielding layers against immune system recognition in so-called stealth liposome formulations. Each polymer is anchored into lipid membrane vesicles that might serve as a nano-vial for membrane embedded hydrophobic or for encaged hydrophilic drugs. The highly polar polymers are assumed to form a loose aqueous PEG layer along the (inner and) outer membrane surface of the hosting vesicle, similar to the glykocalix of a cell. The membrane itself shall still be acessible by small diffusing molecules. We present some details of the polymer packing and its conformational changes as extracted from the analysis of SANS experiments. Results were obtained from suspensions of extruded SUVs (small unilamellar vesicles) that varied in the average amount of polymer that had been anchored into the bilayer sheets, in the number of monomers in the linear polymer chain, and in the average size/curvature of the hosting vesicles.