Berlin 2005 – scientific programme

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DY: Dynamik und Statistische Physik

DY 21: Statistical Physics in Biological Systems

DY 21.6: Talk

Saturday, March 5, 2005, 09:45–10:00, TU H2032

Transition from local to global events in a stochastic medium — •Martin Falcke and Rüdiger Thul — Hahn Meitner Institut, Glienicker Str.100, 14109 Berlin

In the last 2-3 years, it could be shown by a sequence of simulations and analytic calculations that intracellular calcium dynamics is a stochastic nonlinear system. Spatial and temporal structures arise due to fluctuations only. The biological function of intracellular calcium dynamics is to generate transients of high calcium concentration or oscillations. Repetitive wave nucleation is one possibility to achieve this goal. A global event starts from a local fluctuation and travels through the whole system. We investigate the prerequisites for wave nucleation with master and Fokker Planck equations for calcium channel clusters and calculate average frequencies for the occurence of local events.