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DY: Dynamik und Statistische Physik

DY 21: Statistical Physics in Biological Systems

DY 21.7: Vortrag

Samstag, 5. März 2005, 10:00–10:15, TU H2032

Tumor induced angiogenesis: A theoretical model for neo-vascularization and tumor growth — •Heiko Rieger¹, Deok-Sun Lee¹, Raja Paul¹, and Katalin Bartha² — ¹Theoretische Physik, Universität des Saarlandes, 66041 Saarbrücken, Germany — ²Department of Medical Biochemistry, Semmelweis University, Budapest, Hungary

Tumor-induced angiogenesis is the formation of new blood vessels from pre-existing capillaries around a growing tumor in a hypoxic (oxygen-depleted) microenvironment. Hypoxia induces growth factor (GF) synthesis and release from tumor cells (TC), that act on endothelial cells (EC) of nearby blood vessels. Angiogenic sprouting, new vessel formation and vessel dilatation is the result of this interaction leading to favorable tumor growth conditions. We introduce a stochastic hybrid cellular automaton model to describe quantitatively how vascularization develops in a melanoma type tumor. We present results for the spatio-dynamic evolution of the microvascular and tumor density, which reflect a compartmentalization of the tumor into rapidly vascularizing periphery and necrotic regions. Biological implications and possible physical universality classes are discussed.