Berlin 2005 – wissenschaftliches Programm

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HL: Halbleiterphysik

HL 48: Symposium: Bio- and Neurotransistors

HL 48.2: Vortrag

Dienstag, 8. März 2005, 11:15–11:45, TU P270

Interfacing cells with microelectronics — •Günter Wrobel, Frank Sommerhage, Sven Ingebrandt, and Andreas Offenhäusser — Institute Thin Films and Interfaces (ISG-2), Forschungszentrum Jülich, 52425 Jülich, Germany

The interface between functional biological systems and inorganic materials is of central importance for the development of functional bio-assays, biosensors and future information systems. Our efforts aim at developing neuroelectronic systems as well as complex sensors for biological and chemical diagnostics. In order to investigate the principles of the cell-transistor coupling genetically modified cells overexpressing voltage-gated ion-channels are used. In our experiments we have focussed on the time-dependence of the cell-transistor recordings. We examined the electrical coupling of HEK293 cells, which were stably transfected with voltage-gated potassium or chloride channels. Cells were cultured on n- and p-channel field-effect transistors to compare the influence of the device type on the signal shape. The signals of the active ion channels of the whole cell and those in the contact region on the transistor gate are examined using electrophysiological techniques.