Berlin 2005 – scientific programme
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SYBN: Biological and Social Networks
SYBN 2: Biologische und Soziale Netzwerke II
SYBN 2.1: Talk
Monday, March 7, 2005, 12:00–12:20, TU HE101
Regulation of Cell Motility via Functional Phases and Modules — •Hans-Günther Döbereiner1,2, Benjamin J. Dubin-Thaler1, Gregory Giannone1, Harry S. Xenias1, and Michael P. Sheetz1 — 1Department of Biology, Columbia University, New York, NY 10027 — 2Department of Physics, Columbia University, New York, NY 10027
We have observed the existence of distinct phases [1] and dynamic phase transitions [2] in the motile behavior of mouse embryonic fibroblasts. The main phase exhibits periodic contractions of the actomyosin cytoskeleton. These periodic contractions are used by the cell to probe the elasticity of the substrate via integrin linkages [3]. We suggest a hierarchical classification of proteins into modules linked to phase structure, phase regulation parameters, and pure signaling components controlling these parameters. A tentative phase diagram is presented. A phase model of motility could serve as a paradigmatic example for a powerful general ordering principle in quantitative systems biology.
[1] B. Dubin-Thaler, G. Giannone, H.-G. Döbereiner, and M. P. Sheetz, Biophys. J. 86, 1794 (2004).
[2] H.-G. Döbereiner B. Dubin-Thaler, G. Giannone, H. S. Xenias, and M. P. Sheetz, Phys. Rev. Lett. 93, 108105 (2004).
[3] G. Giannone, B. Dubin-Thaler, H.-G. Döbereiner, N. Kieffer, A. R. Bresnick, and M. P. Sheetz, Cell 116, 431 (2004).