Dresden 2006 – wissenschaftliches Programm

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AKB: Biologische Physik

AKB 10: Neuroscience

AKB 10.2: Vortrag

Dienstag, 28. März 2006, 12:00–12:15, ZEU 255

The role of inhibitory feedback for information processing in thalamocortical circuits — •Jörg Mayer, Heinz Georg Schuster, and Jens Christian Claussen — Institut für Theoretische Physik und Astrophysik, Christian-Albrechts Universität, Olshausenstraße 40, 24098 Kiel, Germany

The information transfer in the thalamus is blocked dynamically during sleep or deep anaesthesia, in conjunction with the occurence of spindle waves. We analyze two modeling approaches for a recent experiment by Le Masson et al. on the thalamocortical loop. In a first step, we use a conductance-based neuron model to reproduce the experiment computationally. In a second step, we model the same system by using an extended Hindmarsh-Rose model, and compare the results with the conductance-based model. In the framework of both models, we investigate the influence of inhibitory feedback on the information transfer in a typical thalamocortical oscillator. We find that the extended Hindmarsh-Rose neuron reproduces the experiment better than the conductance-based model. Further, inhibitory feedback leads to stable self-sustained oscillations which mask the incoming input, and thereby reduce the information transfer significantly.[1]

[1] Jörg Mayer, Heinz Georg Schuster, and Jens Christian Claussen, The role of inhibitory feedback for information processing in thalamocortical circuits, arxiv.org e-print q-bio/0510040