Dresden 2006 – scientific programme

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AKB: Biologische Physik

AKB 16: Biological Networks

AKB 16.3: Talk

Wednesday, March 29, 2006, 14:45–15:00, ZEU 255

Architecture of Randomly Evolving Idiotypic Networks — •Holger Schmidtchen and Ulrich Behn — Institut für Theoretische Physik, Universität Leipzig, POB 100 920, 04009 Leipzig

B-Lymphocytes express on their surface receptors (antibodies) of a given specifity (idiotype). Crosslinking these receptors by complementary structures, antigens or antibodies, stimulates the lymphocyte. Thus a large functional network of interacting lymphocytes, the idiotypic network, emerges. Idiotypic networks conceived by Niels Jerne 30 years ago, experience a renewed interest, e.g. in the context of autoimmune diseases. In a previously proposed minimalistic model [1] idiotypes are represented by bitstrings. The population dynamics of the idiotype clones is reduced to a zero–one scheme. An idiotype survives only if it meets enough but not too much complementary structures. We investigate the random evolution of the network towards a highly organized functional architecture which is driven by the influx of new idiotypes, randomly generated in the bone marrow. The vertices can be classified into different groups, which are clearly distinguished, e.g., by the mean life time of the occupied vertices. They include densely connected core groups and peripheral groups of isolated vertices, resembling central and peripheral part of the biological network. We found the building principles of the observed patterns and propose a description of their architecture, which are easily transferable to other patterns and applicable to different system sizes.

[1] M. Brede, U. Behn, Patterns in randomly evolving networks: Idiotypic networks, Phys. Rev. E 67, 031920 (2003)