Dresden 2006 – wissenschaftliches Programm

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AKB: Biologische Physik

AKB 16: Biological Networks

AKB 16.4: Vortrag

Mittwoch, 29. März 2006, 15:00–15:15, ZEU 255

Robustness and evolvability of genetic networks — •Stefan Braunewell and Stefan Bornholdt — Institute for Theoretical Physics, University of Bremen, Otto-Hahn-Allee, 28359 Bremen, Germany

The molecular biological networks that control the processes of a living cell are required to be robust: They simply have to be stable against perturbations to ensure the survival of the organism [1]. On the other hand, organisms are highly evolvable and have proven quite flexible in the course of biological evolution. Therefore, also the genetic control networks should be flexible under evolution [2]. Is robustness evolvable and does network robustness affect evolvability? We here study these questions in the framework of a simple discrete dynamical network model. We develop a new method for modeling noise in genetic networks and use a non-stochastic approach that allows for exact results.

[1] K. Klemm and S. Bornholdt, Topology of biological networks and reliability of information processing, Proc. Natl. Acad. Sci. USA (2005), in press.

[2] S. Bornholdt and K. Sneppen, Neutral mutations and punctuated equilibrium in evolving genetic networks, Phys. Rev. Lett. 81 (1998) 236.