Dresden 2006 – scientific programme
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AKB: Biologische Physik
AKB 30: Poster Session I
AKB 30.18: Poster
Monday, March 27, 2006, 15:30–18:00, P1
Effect of genome sequence on the force induced unzipping of a DNA molecule — •Navin Singh1,2 and Yashwant Singh2 — 1Max Planck Institute for Polymer Research, Mainz, Germany — 2Department of Physics, Banaras Hindu University, Varanasi, India
We considered a dsDNA polymer in which distribution of bases are random at the base pair level but ordered at a length of 18 base pairs and calculated its force elongation behaviour in the constant extension ensemble. The unzipping force F(y) vs. extension y is found to have a series of maxima and minima. By changing base pairs at selected places in the molecule we calculated the change in F(y) curve and found that the change in the value of force is of the order of few pN and the range of the effect depending on the temperature, can spread over several base pairs.