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AKB: Biologische Physik

AKB 30: Poster Session I

AKB 30.37: Poster

Montag, 27. März 2006, 15:30–18:00, P1

The role of lipids with positive curvature in the formation of membrane pores — •Jakob C. Schweizer and Petra Schwille — Biotec/TU Dresden, Tatzberg 47-51, 01307 Dresden

It is assumed that lipids with a positive curvature, e.g. large headgroup and small chain, play an essential role in the formation toroidal structures like membrane pores or edges of planar and supported membranes. Using single-chained lipid probes with an appropriate attachment of the fluorophore should reveal localization and orientation of such lipids within the membrane and therefore migth indicate the involvement in toroidal structures. In a first approach, this can be demonstrated in the case of membrane edges and large pores using simple epi-fluorescence microscopy.