Dresden 2006 – wissenschaftliches Programm

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AKB: Biologische Physik

AKB 30: Poster Session I

AKB 30.40: Poster

Montag, 27. März 2006, 15:30–18:00, P1

Investigation of the mechanical properties of lipid bilayers with nanomechanical cantilever array sensors — •Ioana Pera and Jürgen Fritz — International University Bremen, School of Engineering and Science, 28759 Bremen, Germany

It has been observed in both model and natural systems that the shape and mechanical properties of lipid membranes are influenced by their composition. So far, such properties of bilayers have mainly been studied indirectly at the air-water interface, using lipid monolayers as models or by investigating the surface curvature of lipid vesicles. Here, we are interested in the influence of lipid - lipid and lipid - solid surface interactions on the mechanical properties of lipid bilayers. We report on direct measurements of the bending of microfabricated cantilever arrays upon the formation and modification of physi- and chemisorbed supported lipid bilayers on cantilever surfaces. Implications for the detection of membrane processes with cantilever sensors (such as protein binding, cholesterol incorporation and extraction, or phospholipase activity), along with our primary models will be discussed.