Dresden 2006 – scientific programme

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AKB: Biologische Physik

AKB 40: Poster Session II

AKB 40.29: Poster

Wednesday, March 29, 2006, 16:30–19:30, P3

An Intestinal Drug Transport Model — •Niko Komin and Raúl Toral — IMEDEA, Palma de Mallorca, Spain

Drug absorption in the intestinal tract happens due to two different processes: passive diffusion proportional to the concentration difference and active transport via a molecular pump. The active transport is usually described as a Michaelis-Menten process.

Little is known about the number and location of the pumps (inside/outside the intestine) and its governing parameters. Experiments and nonlinear parameter regression try to know more about the process, but a deeper understanding of the underlying process would facilitate the experimentators work and help on the drug development, meaning less experiments, safer and maybe more specific drugs.

In this work differential equations describing the continuous concentration transport are analysed. Long term and short term solutions are desired. Besides we try to explain the variability in the measurements, introducing variablitiy or noise into the equations.