Dresden 2006 – scientific programme
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AKB: Biologische Physik
AKB 40: Poster Session II
AKB 40.8: Poster
Wednesday, March 29, 2006, 16:30–19:30, P3
Vasculature remodeling in tumor-induced angiogenesis – a stochastic model — •Raja Paul1, Katalin Bartha2, and Heiko Rieger3 — 1BIOMS, IWR, Ruprecht-Karls-University Heidelberg, D-69120 Heidelberg, Germany — 2Department of Medical Biochemistry, Semmelweis University, Budapest, Hungary — 3Theoretische Physik, Universität des Saarlandes, D-66041 Saarbrücken
Based upon a recently introduced model[1] for vascular network remodeling via vessel cooption, regression and growth in tumors[2] we study a dynamically evolving two-dimensional biconnected network incorporating the effect of probabilistic neo-vascularization and vessel collapse. The morphology of a regular vasculature is drastically changed in the presence of an expanding tumor. Independent vessel collapse results in a percolation transition of the network, flow correlated collapse stabilizes the network in the tumor center at a non-vanishing microvascular density (MVD). MVD, blood flow and shear force has been computed for a wide range of parameters and found to be in good qualitative agreement with experimental data[3] for human melanoma.
[1] K. Bartha and H. Rieger, q-bio.TO/0506039.
[2] D. Hanahan and J. Folkman, Cell, 86, 353 (1996).
[3] B. Döme, S. Paku, B. Somlai and J. Tímár, J. Path., 197, 355 (2002).