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AKB: Biologische Physik

AKB 5: Cell Motility II

AKB 5.1: Hauptvortrag

Montag, 27. März 2006, 14:00–14:30, ZEU 255

Cell motility as persistent random motion: theories from experiments — •Henrik Flyvbjerg^1,2, David Selmeczi^2,3, Stephan Mosler², Peter H. Hagedorn¹, and Niels B. Larsen^1,2 — ¹Biosystems Department, Risø National Laboratory, DK-4000 Roskilde, Denmark — ²Danish Polymer Centre, Risø National Laboratory, DK-4000 Roskilde, Denmark — ³Department of Biological Physics, Eötvös Loránd University, H-1117 Budapest, Hungary

Cell migration is essential in many physiological and pathological processes and in emerging medical technologies that depend on it for colonization of biomaterials. Quantitative migration studies rely on motility models for data interpretation. Finding no model in the literature that captures the nature of our data, we used the data to capture the nature of suitable models. An analysis of trajectories followed by motile human keratinocytes and fibroblasts lead to cell-type-specific motility models. These models show that cells have memory, and apparently reflect the cells’ different roles in the organism. The method of analysis is general and may be applied to other motile cell-types and organisms.