Dresden 2006 – wissenschaftliches Programm
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AKSOE: Physik sozio-ökonomischer Systeme
AKSOE 10: Poster Session (posters are expected to be displayed the full day 8:30-18:00)
AKSOE 10.51: Poster
Mittwoch, 29. März 2006, 16:00–18:00, P2
Impact of observational incompleteness on the structural properties of protein interaction networks — •Mathias Kuhnt1,2, Ingmar Glauche3, and Martin Greiner2 — 1Institut für Theoretische Physik, Technische Universität Dresden, D-01062 Dresden, Germany — 2Corporate Technology, Information & Communications, Siemens AG, D-81730 München, Germany — 3Institut für Medizinische Informatik, Statistik und Epidemiologie, Universität Leipzig, Härtelstr. 16/18, D-04107 Leipzig, Germany
The observed structure of protein interaction networks is corrupted by many false positive/negative links. This observational incompleteness is abstracted as random link removal and a specific, experimentally motivated (spoke) link rearrangement. Their impact on the structural properties of gene-duplication-and-mutation network models is studied. For the degree distribution a curve collapse is found, showing no sensitive dependence on the link removal/rearrangement strengths and disallowing a quantitative extraction of model parameters. The spoke link rearrangement process moves other structural observables, like degree correlations, cluster coefficient and motif frequencies, closer to their counterparts extracted from the yeast data. This underlines the importance to take a precise modeling of the observational incompleteness into account when network structure models are to be quantitatively compared to data.