Dresden 2006 – wissenschaftliches Programm

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CPP: Chemische Physik und Polymerphysik

CPP 22: SYMPOSIUM Microfluidics II: Soft objects in flow, open geometries

CPP 22.2: Vortrag

Donnerstag, 30. März 2006, 14:30–14:45, ZEU 160

Dynamics and Formation of Actin Bundles in Extensional Flow — •Dagmar Steinhauser, Sarah Köster, and Thomas Pfohl — Max-Planck-Institut für Dynamik und Selbstorganisation, Bunsenstrasse 10, 37073 Göttingen

We are interested in the dynamics of biopolymers under extensional flow and the formation of condensed structures, bundles and networks, induced by inter-chain and intra-chain linker molecules. In particularly the bundling behavior of actin filaments in presence of actin binding proteins (e.g. α-actinin) or multivalent ions is considered. Actin filaments as well as their bundles and networks are visualized in continuous flow by stroboscopic laser light illumination. Using a hydrodynamic focusing device we are able to observe the evolution of the bundling of individual filaments. A detailed analysis of the fluctuations of the formed bundles leads to information about their stiffness in dependence on the number of actin filaments.