Dresden 2006 – scientific programme

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MA: Magnetismus

MA 32: Magnetic Particles / Clusters

MA 32.14: Talk

Thursday, March 30, 2006, 18:30–18:45, HSZ 401

Investigation of biological research issues with superparamagnetic nanoparticles by differential fluxgate magnetorelaxometry — •Erik Heim, Kai Pöhlig, Frank Ludwig, and Meinhard Schilling — TU Braunschweig, Institut für Elektrische Messtechnik und Grundlagen der Elektrotechnik, Hans-Sommer-Str. 66, D-38106 Braunschweig, GERMANY

A promising bioanalytical application of superparamagnetic iron oxid nanoparticles (SPIOs) is the Magnetic Relaxation ImmunoAssay (MARIA). Commonly SPIOs are used as a contrast agent in magnetic resonance imaging. In MARIA biological targets are specifically marked with SPIOs. Here the relaxation signal of magnetized SPIOs is measured. Magnetic nanoparticles have the advantages of being non-toxic, that they can be used in opaque medium and that they are suitable for homogeneous assays at the same time. For MARIA the ideal SPIOs are monodisperse with a core diameter of 20 nm. So far commercially available SPIOs are not optimized for MARIA. Therefore we fractionize and functionalize these ferrofluids. As a model system to study binding kinetics we use SPIOs functionalized with streptavidin and biotinilated binding partners.

Financial support by the DFG via SFB578 is acknowledged.