Düsseldorf 2007 – wissenschaftliches Programm

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MO: Fachverband Molekülphysik

MO 26: Poster: Biomolecules

MO 26.2: Poster

Dienstag, 20. März 2007, 16:30–18:30, Poster A

Screening Biological Systems by Raman Scattering Techniques — Towards Specific Characterization of Tumors on a Molecular Level — •Patrice Donfack, Malte Sackmann, and Arnulf Materny — International University Bremen IUB (Jacobs University Bremen as of Spring 2007), Germany

Cancer is a severe disease connected with progressive radical molecular distortions in the host cells. Since many years vibrational Raman spectroscopy (RS) and related techniques have been recognized as powerful tools for probing molecular vibrations giving rise to molecular fingerprints. In a non-destructive and non-invasive way even relatively small molecular distortions can be detected. An early detection of the onset of biological deterioration is possible only if specific molecular information can be obtained that becomes distinguishable as soon as changes occur. Understanding molecular events in biological systems at molecular level appears would be an outstanding attainment allowing for a monitoring of the behavior of biological systems and the discrimination between healthy and cancerous states. Obviously, a potential approach would consist of a combination of many methods. We are applying spontaneous RS, surface enhanced Raman scattering (SERS) as well as biochemical molecular recognition techniques. Our goal is to differentiate and histopathologically assign spectroscopic changes that occur between healthy cells or tissue and to identify tumors in different stages of their development. Results obtained from RS and SERS applied to tissue sections and cells for different experimental environments and conditions are discussed.