Regensburg 2007 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 16: Poster Session I

BP 16.18: Poster

Dienstag, 27. März 2007, 17:00–19:30, Poster D

Stretching of a DNA/HU-protein complex in SMD simulations — •Carsten Olbrich and Ulrich Kleinekathöfer — International University Bremen (Jacobs University Bremen as of spring 2007), Campus Ring 1, 28759 Bremen, Germany

HU is a member of a family of prokaryotic proteins that interact with the DNA in a non-specific way. Its major function is the binding, compaction and stabilization of DNA. We applied steered molecular dynamic (SMD) simulations to DNA which is bonded to a HU protein and present some results in comparison with experiments done with optical tweezers. These show discrete steps during disruption. The goal is to analyze in detail these steps with the help of MD simulations.