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BP: Fachverband Biologische Physik

BP 16: Poster Session I

BP 16.35: Poster

Dienstag, 27. März 2007, 17:00–19:30, Poster D

Cellular Potts Model based simulation of endothelial network formation — •Martin Peglow and Heiko Rieger — Theoretische Physik, Universität des Saarlandes, PF 151150, D-66041 Saarbrücken

The Cellular Potts Model is a cell centered based Monte Carlo approach to development biology, focusing on intercellular adhesion forces. In an early stage of embryogenesis the capillary network, the first organ in vertebrates, is built to supply other tissues with oxygen and nutrients. Cells beeing self organized, there has to be a cell communication system which can describe the underlying mechanisms of vaculogenesis and angiogenesis. We study a theoretical model that describes chemotactic diffusion of growth factors, which are produced by autocrine cells and decay within the extracellular matrix. For a better understanding of this process, which has already been shown in vitro, we studied the influence of different strengths of a contact inhibited mechanism on the structure and shape of the network in 2d and 3d. Contact inhibition here means that chemotactic filopodia were supressed at cell-cell interfaces.