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BP: Fachverband Biologische Physik

BP 25: Oscillatory Systems

BP 25.6: Vortrag

Donnerstag, 29. März 2007, 16:00–16:15, H44

A bidomain threshold model of intracellular calcium release — •Rüdiger Thul¹, Stephen Coombes¹, and Greg D. Smith² — ¹School of Mathematical Sciences, University of Nottingham, Nottingham, NG7 2RD, UK — ²Department of Applied Sciences, The College of William and Mary, Williamsburg, Virginia, 23187, USA

We introduce a bidomain threshold model of intracellular calcium release. By the explicit construction of travelling wave solutions we are able to probe the dependence of wave speed on physiologically important parameters, including the rate of calcium pumping between the endoplasmic reticulum and the cytosol. Importantly we develop a linear stability analysis that predicts the onset of front instabilities, leading to the emergence of waves that propagate in a back-and-forth manner. Direct numerical simulations are used to confirm our travelling wave predictions.