Regensburg 2007 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 26: Poster Session II

BP 26.17: Poster

Donnerstag, 29. März 2007, 17:00–19:30, Poster B

Stochastic Effects In Drug Transport Through Cell Monolayers (An Analogue To Enzymatic Reactions) — Niko Komin and •Raúl Toral — IMEDEA (CSIC-UIB), Campus Universitat Illes Balears, E-07122 Palma de Mallorca, Spain

The transport processes through multiple cellular membranes is the focus of this work. In the simplest case the system consists of three compartments: an apical and a basolateral volume and the cellular volume in between. The boundaries are the lipid bilayers which (some) molecules can traverse passively, following the concentration gradient. Additionally transporter proteins are integrated into one or both lipid bilayers which actively move molecules from one side to the other (against the concentration gradient, if necessary). Transporter proteins and enzymes can be described by the same equations.

A harmonic approximation of the equations leads to solutions with good accordance to the unsimplified system. From here on we study the source of variability in the measurements. Uncertainties in parameters as well as a small system size (low number of particles) yield uncertainties in the time evolution of the concentrations. The dependences are not lineal.