Regensburg 2007 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 26: Poster Session II

BP 26.41: Poster

Donnerstag, 29. März 2007, 17:00–19:30, Poster B

Facilitated permeation through porins — Catalin Chimerel, Tivadar Mach, Helge Weingart, Ulrich Kleinekathöfer, and •Mathias Winterhalter — IUB-Bremen, Campusring 1, 28725 Bremen

The outer cell wall of Escherichia coli contains a number of channel forming proteins called porins. Such channels allow e.g. bacteria to harvest nutrients. We characterise e.g. the transport of antibiotics across such membrane channels on a single molecular level by time resolved ion current. Measureing the ion current fluctuation in presence of different concentrations of penicilins revealed a clear correlation between permeation and biological activity.