Regensburg 2007 – wissenschaftliches Programm

Bereiche | Tage | Auswahl | Suche | Downloads | Hilfe

CPP: Fachverband Chemische Physik und Polymerphysik

CPP 22: POSTER: INTERNAL SYMPOSIUM Optical Spectrosopy

CPP 22.8: Poster

Mittwoch, 28. März 2007, 16:00–18:30, Poster B

Diffusion of biomolecules in mesoporous silica materials — •Timo Lebold, Christophe Jung, Johanna Kirstein, Lea Mühlstein, Thomas Bein, and Christoph Bräuchle — Center for Nanoscience, Ludwig-Maximilians-Universität München, Department Chemie und Biochemie, Butenandtstraße 5-13, Haus E, 81377 München, Germany

Nanoporous channel systems, for example M41S-materials, form a class of very promising host systems. Various guests can be embedded into their pores. A highly interesting application could be drug-delivery systems based upon such mesoporous silica materials. However, an essential prerequisite for the development of such systems is the detailed knowledge of the molecular dynamics and the host-guest interactions within the porous network. The diffusional behaviour of fluorescent molecules is elucidated in our group by highly-sensitive single-molecule microscopy techniques: wide-field and confocal fluorescence microscopy. They provide a unique insight into the molecular trajectories and the underlying mechanisms. This study focuses on fluorescently labelled biomolecules which are incorporated as guests into calcined mesoporous structures as well as structures with an internal functionalization of the pores. Their dynamics and their interaction with the pore inner surface are investigated in detail. This allows us to characterize the diffusion processes that are essential for the release of biomolecules from mesoporous silica materials in their role as drug-delivery systems.