Regensburg 2007 – wissenschaftliches Programm
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MM: Fachverband Metall- und Materialphysik
MM 35: SYBM Bioinspired Materials
MM 35.20: Poster
Donnerstag, 29. März 2007, 18:45–20:45, H16
Structural adaptation in trabecular bone — •John Dunlop1, Markus Hartmann2, Yves Bréchet3, Peter Fratzl1, and Weinkamer Richard1 — 1Department of Biomaterials, Max Planck Institute of Colloids and Interfaces, Research Campus Golm, 14424, Potsdam, Germany — 2Service de Chimie Moléculaire, C.E.A./Saclay, Bat. 125, 91191 Gif-sur-Yvette cedex, France — 3Groupe Physique du Métal, LTPCM/ENSEEG INPG, Domaine Universitaire de Grenoble, 38402 Saint Martin d'Hères, France
The structure of trabecular bone results from the complex interaction between bone producing cells (osteoblast), bone absorbing cells (osteoclasts) and signalling cells (osteocytes), and the performance of the bone matrix itself. One of the important factors that regulates the trabecular architecture is mechanical loading. This can be generalised by the Wolff-Roux law: that is, bone in general is deposited where it is mechanically needed and removed where it is not. Changes in mechanical loading are clearly seen to affect cellular activity and also to modify the resultant bone architecture. The precise details of how cells "feel" a stimulus and exactly how they respond are not known, although there are many suggestions that have been proposed. Computer simulation techniques are ideally suited to testing these theories. In this contribution a 3D lattice model of trabecular bone is presented and used to investigate the link between individual cell response and trabecular architecture through both the "remodelling" and "stimulus" rules.