Regensburg 2007 – scientific programme

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ST: Fachverband Strahlen- und Medizinphysik

ST 9: Strahlenbiophysik

ST 9.4: Talk

Tuesday, March 27, 2007, 16:45–17:00, Ch 12.0.16

Cell survival studies for moving targets — •Alexander Schmidt, Christoph Bert, Nami Saito, Cläre von Neubeck, Eike Rietzel, and Gerhard Kraft — GSI-Biophysics, Darmstadt, Germany

More than 330 patients with static tumors have been treated at GSI with a scanned C-12 beam. For targets that are subject to respiratory motion, treatment is not yet possible because target motion and scanning motion interfere.

GSI is developing a motion compensation system to compensate target motion by adaptation of each individual Bragg peak position. Within this project, the GSI treatment planning software TRiP was extended to calculate physical dose distributions in the presence of motion. These motion extensions were experimentally validated [1]. Recently we included the calculation of cell survival for moving targets. To validate the software, a program of experimental studies with biological samples has been started.

In a first set of experiments, living cell cultures were placed on a periodically moving table and irradiated with and without motion compensation. Results are compared to reference cell cultures that were static during standard irradiations. Furthermore, measured cell survival distributions are compared to calculated distributions for all irradiation schemes.

[1] Bestrahlungsplanung für bewegte Zielvolumina in der Tumortherapie mit gescanntem Kohlenstoffstrahl, Christoph Bert, PhD-thesis (2006)