Berlin 2008 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 1: Cell Migration and Tissue Dynamics

BP 1.2: Hauptvortrag

Montag, 25. Februar 2008, 10:00–10:30, C 243

Regulation of Growth during Development: Role of Mechanics — •Lars Hufnagel — EMBL Heidelberg, Heidelberg, Germany

A fundamental and unresolved problem in animal development is the question of how a growing tissue knows when it has achieved its correct final size. A widely held view suggests that this process is controlled by morphogen gradients, which adapt to tissue size and become flatter as tissue grows, leading eventually to growth arrest. I will discuss the spatio-temporal dynamics of that the decapentaplegic (Dpp) morphogen distribution in the developing Drosophila wing imaginal disk and present an alternative model for wing size determination and proliferation control in tissues.