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BP: Fachverband Biologische Physik

BP 2: DNA and Chromatin

BP 2.8: Vortrag

Montag, 25. Februar 2008, 12:30–12:45, PC 203

Thermodynamic Analysis of Interacting Nucleic Acids with Application to Biosensing Devices — •Justin Bois¹ and Niles Pierce² — ¹Max Planck Institute for the Physics of Complex Systems, Dresden, Germany — ²California Institute of Technology, Pasadena, CA, USA

DNA and RNA are versatile construction materials. By appropriately designing base sequences, synthetic nucleic acid systems can be programmed to self-assemble into complex structures. An understanding of the underlying free energy landscapes of these systems is crucial for their design, characterization, and control. This talk will focus on theoretical and computational tools to characterize the equilibrium properties of an entire test tube of interacting nucleic acid strands. The utility of the approach will be demonstrated by elucidating the empirical behavior of a new class of DNA-based instrument-free biosensors currently under development.