Berlin 2008 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 23: Electrical Stimulation and Recording

BP 23.1: Vortrag

Donnerstag, 28. Februar 2008, 12:00–12:15, PC 203

Study of neural cells on organic semiconductor ultra thin films — •Eva Bystrenova¹, Ilaria Tonazzini¹, Pablo Stoliar¹, Pierpaolo Greco¹, Marta Jelitai², Adina Lazar¹, Martin Huth³, Soumya Dutta¹, Chiara Dionigi¹, Marcello Cacace¹, Bert Nickel³, Emilia Madarasz², Claudia Martini⁴, and Fabio Biscarini¹ — ¹ISMN-CNR, Bologna, Italy — ²IEM- HAS, Budapest, Hungary — ³LMU, Munich, Germany — ⁴Dept. PNPB, Univ. of Pisa, Italy

Many technological advances are currently being developed for nano- fabrication, offering the ability to create and control patterns of soft materials. We report the deposition of cells on organic semiconductor ultra-thin films. This is a first step towards the development of active bio/non bio systems for electrical transduction. Thin films of pentacene, whose thickness was systematically varied, were grown by high vacuum sublimation. We report adhesion, growth, and differentiation of human astroglial cells and mouse neural stem cells on an organic semiconductor. Viability of astroglial cells in time was measured as a function of the roughness and the characteristic morphology of ultra thin organic film, as well as the features of the patterned molecules. Optical fluorescence microscope coupled to atomic force microscope was used to monitor the presence, density and shape of deposited cells. Neural stem cells remain viable, differentiate by retinoic acid and form dense neuronal networks. We have shown the possibility to integrate living neural cells on organic semiconductor thin films. Project EU-NMP-STRP 032652 BIODOT.