Berlin 2008 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 26: Posters II

BP 26.38: Poster

Donnerstag, 28. Februar 2008, 17:00–19:30, Poster A

Emergent vascular network inhomogeneities and resulting blood flow patterns in a growing tumor — •Michael Welter and Heiko Rieger — Theoretische Physik, Universität des Saarlandes, 66041 Saarbrücken, Germany

We present and analyze a theoretical model for tumors growing in a host tissue that is vascularized with an arterio-venous blood vessel network. The tumor grows by coopting a massive vascular plexus which is progressively created by angiogenic sprouting. In the center, drastic vessel regression is apparent, accompanied by necrosis in unperfused regions. Few vessels survive, threading the tumor, cuffed by viable tumor cells (TCs). Via Monte-Carlo simulation, we analyze our hybrid cellular-automaton model where this behavior is realized by stochastical processes like sprouting, vessel removal, TC proliferation or TC death. Further we show current simulation results of the time-dependent distribution of drug injected into the blood stream.