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BP: Fachverband Biologische Physik

BP 26: Posters II

BP 26.42: Poster

Donnerstag, 28. Februar 2008, 17:00–19:30, Poster A

Signal integration and stochastic decision making phosphorelay signal transduction — •Ilka Bischofs^1,2, Josh Hug¹, Aiwen Liu¹, David Lee¹, Denise Wolf², and Adam Arkin^1,2 — ¹University of Berkeley, USA — ²Lawrence Berkeley Lab, Berkeley, USA

Phosphorelays are common architectures for integrating multiple signals in prokaryotic signal transduction. In B. subtilis a phosphorelay controls stress response induction in response to adverse environmental conditions. We investigate mechanisms of signal integration and stochastic decision making by time lapse microscopy of fluorescent reporter strains to quantify the dynamics of population heterogeneity. Through theoretical modelling we furthermore demonstrate that the complex feedback architecture found in the spo-relay confers robust signal amplification and robust integration of starvation and quorum signals.