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BP: Fachverband Biologische Physik
BP 26: Posters II
BP 26.45: Poster
Donnerstag, 28. Februar 2008, 17:00–19:30, Poster A
Simulation of protein kinase C alpha (PKCα) membrane translocation processes — •Martin Peglow and Heiko Rieger — Theoretische Physik, Universität des Saarlandes, PF 151150, D-66041 Saarbrücken
PKCα is a versatile key for decoding the cellular calcium toolkit. During their measurements of PKCα membrane translocations, which are activated through intracellular Ca2+ release, Reither and Lipp [1] found two populations of so called Local Translocation Events (LTEs). One population whose life times correspond to the duration of the underlaying Ca2+-signals and a second population the so called long lasting LTEs ( T > 4s ). The source or appearance of the long lasting LTEs can’t be explained for sure. Theoretical assumptions for possible mechanisms shall be verified by our simulations. An efficient Monte Carlo algorithm for simulations of reaction-diffusion kinetics in single cells, the ”Next Subvolume Method” [2], is presented here.
[1] Dr. Gregor Reither, EMBL Heidelberg and Prof. Peter Lipp, Institut für Molekulare Zellbiologie Universität des Saarlandes, JCB, 174, 521,
(2006)
[2] J. Elf, A. Doncic, M. Ehrenberg, Proceeding of SPIE, 5110, (2003)