Berlin 2008 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 27: Membrane Morphology and Adhesion

BP 27.1: Hauptvortrag

Freitag, 29. Februar 2008, 10:15–10:45, C 243

Secretion of protein-coated vesicles — •Pierre Sens — CNRS, PhysicoChimie Théorique - ESPCI, Paris

Cellular trafficking generally involves spherical or tubular membrane vesicles, the formation of which often rely on the aggregation of membrane proteins (COPI, COPII, Clathrin and Caveolae). I will review some of the theoretical models that have been developed to describe this phenomenon, with particular emphasis on systems driven out of equilibrium by the expenditure of energy through the activity of GTPases proteins. I will show how vesicle secretion and traffic can be very efficiently regulated by the alteration of the GTP hydrolysis cycle, which is known to be affected, for instance, by the presence of cargo.