Berlin 2008 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 28: Molecular Recognition

BP 28.1: Vortrag

Freitag, 29. Februar 2008, 10:45–11:00, PC 203

Influence of Sequence Correlations on Molecular Recognition — •Hans Behringer and Friederike Schmid — Fakultät für Physik, Universität Bielefeld, D-33615 Bielefeld

Equilibrium aspects of molecular recognition are investigated using coarse-grained models for the recognition process of two rigid biomolecules. To this end, a two-stage approach is adopted. First, the structure of the target molecule is fixed and learned by a probe molecule resulting in an ensemble of probe sequences. In a second step the recognition ability of the designed probe ensemble with respect to the chosen target sequence is tested by comparing the free energy of association with the previously fixed target structure and a different competing structure. Particular attention is paid to the influence of correlations in the hydrophobicity distributions on the recognition sites of the molecules on the recognition ability of the probe molecules.

Behringer, H., A. Degenhard, F. Schmid 2007, Coarse-Grained Lattice Model for Investigating the Role of Cooperativity in Molecular Recognition, Phys. Rev. E 76, 031914.