Berlin 2008 – scientific programme

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BP: Fachverband Biologische Physik

BP 8: Active Filament Networks

BP 8.3: Talk

Tuesday, February 26, 2008, 10:45–11:00, C 243

Adhesion Patches in Early Cell Spreading — •Hans-Günther Döbereiner, Marcus Prass, Meike Gummich, and Jac-Simon Kühn — Institut für Biophysik, Universität Bremen

Cell motility is controlled by an active polymer gel enclosed by a complex membrane relaying extracellular signals and forces. We report on the dynamics of spreading mouse embryonic fibroblasts. Advancing membrane edges and adhesions patterns on two-dimensional substrates can be well characterized by total internal reflection fluorescence and reflection interference contrast microscopy. One finds various dynamic phases [1] and collective modes [2]. We discuss characteristic spatial-temporal correlations and relate our findings to theoretical calculations [3]. Especially, we present recent results on adhesion patches in early spreading events.

[1] H.-G. Döbereiner et al., Phys. Rev. Lett. 93, 108105 (2004).

[2] H.-G. Döbereiner et al., Phys. Rev. Lett. 97, 38102 (2006).

[3] R. Shlomovitz and N. S. Gov, Phys. Rev. Lett 98, 168103 (2007).