Berlin 2008 – wissenschaftliches Programm
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 13: Colloidal and Nanoparticles
CPP 13.1: Vortrag
Dienstag, 26. Februar 2008, 15:00–15:15, C 264
Micromechanics of gas filled Microballoons — •Paulo Fernandes1,2, George Tzvetkov3,4, Rainer Fink3, and Andreas Fery1 — 1Physikalische Chemie II, Universität Bayreuth, Bayreuth, Germany — 2Max-Planck-Institut für Kolloid- und Grenzflächenforschung, Potsdam, Germany — 3Physikalische Chemie II,Universität Erlangen-Nürnberg, Erlangen, Germany — 4Swiss Light Source, Paul Scherrer Institut, 5232 Villigen, PSI, Switzerland
Gas filled MicroBalloons (MBs) are today highly valued research subjects mainly due to their potential use in medical applications where they impose themselves as targeted drug delivery systems and contrast agents for ultrasonic imaging. Intense research has been devoted to the development of MB systems. Their mechanical and adhesion properties are of interest since these determine the micro containers behavior and stability in applications. We introduce novel AFM-based methods for quantifying both mechanics and adhesion properties.
We use a combination of the colloidal probe AFM technique and an inverted optical microscope. The deformation behavior of individual MBs is characterized with AFM Force Spectroscopy measurements. We analyze the dependence of the profiles with MB radius at different temperatures (room and body temperature). Scanning Transmission X-ray Microscopy (STXM) experiments proved to be very appropriate to study the MBs. Quantitative analysis of the resulting transmission profiles allowed us to characterize the MBs properties.