Berlin 2008 – scientific programme

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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 14: Membranes

CPP 14.5: Talk

Tuesday, February 26, 2008, 16:00–16:15, C 230

Dynamics of Phospholipids in the Stabilizer Layer of Dispersed Lipid Nanoparticles Investigated by Quasielastic Neutron Spectroscopy — •Tobias Unruh, Sebastian Busch, and Christoph Smuda — Technische Universität München, Forschungsneutronenquelle Heinz Maier-Leibnitz (FRM II) and Physik Department E13, Garching, Germany

Dispersions of colloidal lipid particles such as triglyceride nanoparticles are used as delivery systems for intravenous administration of drugs. The stabilizing properties of the surfactant layer in the interface between the nanoparticles and the aqueous dispersion medium are determined i.a. by the dynamics of the stabilizer molecules, which holds in particular if the dispersed particles undergo rapid shape or size changes as e.g. during their production in a homogenizer or their crystallization after preparation [1].

Investigations on the dynamics of phospholipid molecules in dispersions of alkanes and triglycerides performed by quasielastic neutron spectroscopy (QENS) will be presented. The measurements were carried out at the high resolution time--of--flight spectrometer TOFTOF of the FRM II in Garching. Due to the high neutron flux of the instrument the investigation of samples with only 20 mg of phospholipid in the beam was possible. The dynamics of the phospholipids is compared to their dynamics in the bilayers of small unilamellar vesicles (SUVs) and the effect of the addition of a co--surfactant on the phospholipid dynamics will be discussed.

[1] K. Westesen, B. Siekmann, Int. J. Pharm., 151 (1997) 35