Berlin 2008 – scientific programme

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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 17: SYMPOSIUM Driven Soft Matter II

CPP 17.3: Talk

Tuesday, February 26, 2008, 15:00–15:15, C 130

Giant DNA Diffusion — •Ralf Eichhorn, Jan Regtmeier, Alexandra Ros, Dario Anselmetti, and Peter Reimann — Universität Bielefeld, Fakultät für Physik, D-33615 Bielefeld

It has been predicted theoretically that particle diffusion in non-equilibrium systems can be enhanced by orders of magnitude, for instance, when the particle is moving in a periodic potential and the non-equilibrium conditions are established by an external static (tilting) force [1,2]. Recently, this effect has been demonstrated experimentally for colloidal particles [3]. We investigate this phenomenon experimentally and theoretically for λ (48.5 kbp) and T2 (164 kbp) DNA in a structured microfluidic device. The periodic potential landscape is created by electrodeless dielectrophoresis, and the tilting force is realized by electrophoresis. The observed giant diffusion is sensitive to the length of the DNA-fragment, and thus has potential application in DNA purification.

[1] P. Reimann, C. Van den Broeck, H. Linke, P. Hänggi, J.M. Rubi, and A. Perez-Madrid, Phys. Rev. Lett. 87, 010602 (2001).

[2] P. Reimann, C. Van den Broeck, H. Linke, P. Hänggi, J.M. Rubi, and A. Perez-Madrid, Phys. Rev. E 65, 031104 (2002).

[3] S. H. Lee, D. G. Grier, Phys. Rev. Lett. 96, 190601 (2006).