Berlin 2008 – scientific programme

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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 35: Interfaces

CPP 35.5: Talk

Friday, February 29, 2008, 11:45–12:00, C 130

Unspecific adsorption of protein films: dynamics and morphology — •Yvonne Schmitt, Hendrik Hähl, Hubert Mantz, and Karin Jacobs — Saarland University - Department of experimental physics, 66123 Saarbrücken, Germany

Protein adsorption takes place whenever a surface is in contact with a protein solution and can for example lead to fouling. The control of adsorption therefore is of crucial importance for many boilogical and biomedical applications like dentistry and the design of implants. By performing in-situ AFM scans in a liquid environment it is possible to gain insight in the complex process of unsecific protein adsorption. The dynamics was monitored via a series of AFM images. The characterization of the spatial protein distribution is done by means of integral geometric methods (Minkowski-functionals) that allow to distinguish between random sequential adsorption and guided adsorption and gives an objective description of the morphology of the protein film. The experimental results will be compared with recent simulations in order to develop a comprehensive description of the the adsorption process which could possibly allow to predict the next adsorption sites for a given protein arrangement.