Berlin 2008 – wissenschaftliches Programm

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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 36: Biopolymers and Biological Systems

CPP 36.1: Vortrag

Freitag, 29. Februar 2008, 10:30–10:45, C 264

Spin Label EPR on Biological Systems — •Malte Drescher — Emmy-Noether-Gruppe am FB Chemie, Universität Konstanz, Fach M639, 78457 Konstanz

In spite of significant progress, the challenging areas for structure determination in biological systems are still ample: Membrane proteins, protein-protein interactions and membrane association are important for biological function, but because of the amphipathic nature of the first and the intrinsic disorder of the latter systems, conventional methods of structure determination usually do not work. By advanced EPR methods the interaction between spin labels can be measured from 5 Å to 5 nm. Paramagnetic labels can be attached to proteins, nucleic acids and lipids, and as native paramagnetic centres are scarce, the method is background free. Examples of applications to proteins and membranes will be discussed.