Berlin 2008 – scientific programme

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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 9: POSTERS Single Molecules, Biopolymers, Membranes

CPP 9.22: Poster

Monday, February 25, 2008, 16:45–19:00, Poster A

Investigations on the Structure and Dynamics of DMPC-Monolayers used as Stabilizers in Colloidal Dispersions — •Sebastian Busch, Christoph Smuda, and Tobias Unruh — Forschungsneutronenquelle Heinz Maier-Leibnitz and Physik Department E13, Technische Universität München, Munich, Germany

Many modern drugs are not water-soluble. To facilitate their intravenous applicability, a drug carrier has to be employed. Dispersions of lipid nanoparticles stabilized by dimyristoylphosphatidylcholine (DMPC) are promising candidates. It has been shown [1] that not only the drug release rate but also the storage stability of these systems highly depends on the properties of the stabilizer. These properties were investigated i. a. by small angle X-ray scattering [2], revealing that the structure of the monolayer is clearly distinct from the well-known structure of bilayers. A series of experiments aiming to determine the dynamic characteristics of DMPC-monolayers was carried out at the cold neutron time–of–flight spectrometer TOFTOF at the Forschungsneutronenquelle Heinz Maier-Leibnitz in Garching bei München. First results are presented and discussed.

[1] K. Westesen, B. Siekmann, Int. J. Pharm., 151 (1997) 35; H. Bunjes, M. H. J. Koch, K. Westesen, J. Pharm. Sci. 92 (2003) 1509; H. Bunjes, F. Steiniger, W. Richter, Langmuir 23 (2007) 4005

[2] T. Unruh, J. Appl. Cryst. 40 (2007) 1008