Berlin 2008 – wissenschaftliches Programm

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DS: Fachverband Dünne Schichten

DS 38: Vibrational Spectroscopy of Nanolayers with Optical Probes

DS 38.3: Hauptvortrag

Freitag, 29. Februar 2008, 16:15–16:45, H 2013

Tip enhanced Raman scattering on biological samples — •Volker Deckert — ISAS - Institute for Analytical Sciences, Dortmund, Germany

Recently optical techniques that reveal lateral resolution well beyond the diffraction limit became more and more accessible. In particular the combination of near-field optics and Fluorescence spectroscopy proved to be very successful. Since Raman spectroscopy is a comparable insensitive spectroscopic technique progress here was much slower. Just with the combination of field-enhancing techniques, near-field optical techniques could be combined with Raman methods. Especially Tip-Enhanced Raman Scattering (TERS) is a technique that uniquely combines the best of he two worlds. Her applications on biological samples ranging from single cells, single virus particles, to single molecules will be shown. Thus demonstrating the capabilities of TERS. Specifically TERS experiments on a single RNA strand will be discussed and the issue of direct label free sequencing of DNA will be addressed.