Berlin 2008 – wissenschaftliches Programm
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DY: Fachverband Dynamik und Statistische Physik
DY 5: Statistical physics in biological systems (joint session DY/BP)
DY 5.1: Vortrag
Montag, 25. Februar 2008, 14:30–14:45, MA 001
Point Mutations Effects on Charge Transport Properties of the Tumor-Suppressor Gene p53 — •Rudolf A. Roemer1, Chi-Tin Shih2, and Stpehan Roche3 — 1Department of Physics and Centre for Scientific Computing, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK — 2Department of Physics, Tunghai University, 40704 Taichung, Taiwan — 3CEA/DSM/DRFMC/SPSMS, 17 avenue des Martyrs, 38054 Grenoble, France
We report on a theoretical study of point mutations effects on charge transfer properties in the DNA sequence of the tumor-suppressor p53 gene. On the basis of effective tight-binding models which simulate hole propagation along the DNA, a statistical analysis of mutation-induced charge transfer modifications is performed. In contrast to non-cancerous mutations, mutation hotspots tend to result in significantly weaker changes of transmission properties. This suggests that charge transport could play a significant role for DNA-repairing deficiency yielding carcinogenesis.