Berlin 2008 – wissenschaftliches Programm
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O: Fachverband Oberflächenphysik
O 76: Organic, Polymeric, Biomolecular Films - also with Adsorbates
O 76.8: Vortrag
Donnerstag, 28. Februar 2008, 17:00–17:15, MA 043
High Frequency QCM Flow Cell with Enhanced Accuracy for Liquid and Biochemical Sensing — •Brigitte Paula Sagmeister1, Hermann Gruber2, and Reinhard Schwödiauer1 — 1Soft Matter Physics, Johannes Kepler University, Altenbergerstrasse 69, 4040 Linz, Austria — 2Institute for Biophysics, Johannes Kepler University, Altenbergerstrasse 69, 4040 Linz, Austria
Throughout the last twenty years, acoustic wave sensors have been proven to be an extremely sensitive and accurate device for a wide variety of physical, chemical and biochemical sensing applications. Systems based on thickness sheer mode (TSM) quartz resonators, working in a liquid environment with resonance frequencies between 5 and 15 MHz, are already established for real-time measuremets of biochemical interactions and commercially available on the market. The utilisation of high frequency fundamental (HFF) quartz resonators, with resonance frequencies up to 150 MHz (and beyond), could further improve the sensitivity of such systems by orders of magnitude. We present a fully biocompatible flow cell, designed for HFF quartz resonators which, in spite of their small size, can be removed and exchanged quickly and with ease . The system performance is evaluated and quantified by a number of experiments including various viscosity measurement of sugar based solutions, the detection of a BSA proteine monolayer and other biochemical reactions. We further address some specific problems especially related to reusability and cleaning procedures.